Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SMAP1 |
| Gene Name: | SMAP1 |
| Protein Full Name: | Stromal membrane-associated protein 1 |
| Mass (Da): | 50368 |
| Number AA: | 467 |
| UniProt ID: | Q8IYB5 |
| Locus ID: | 60682 |
| COSMIC ID: | SMAP1 |
| Gene location on chromosome: | 6q13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.39 |
| Deregulated in translocations: | t(6;11)(q13;q23) --> MLL-SMAP1 fusion protein found in some acute leukemias |
| Normal role description: | SMAP1 is a GTPase activating protein that acts on ARF6. It also plays a role in clathrin-dependent endocytosis. The translocation, t(6;11)(q13;q23), resulting in the fusion protein, MLL-SMAP1, hase been observed in some acute leukemias. |