Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FANCM |
| Gene Name: | FANCM |
| Protein Full Name: | Fanconi anemia group M protein |
| Alias: | ATP-dependent RNA helicase FANCM; FAAP250; FACM; Fanconi anemia, complementation group M; Fanconi anemia-associated polypeptide of 250 kDa; Hef; KIAA1596 |
| Mass (Da): | 232190 |
| Number AA: | 2048 |
| UniProt ID: | Q8IYD8 |
| Locus ID: | 57697 |
| COSMIC ID: | FANCM |
| Gene location on chromosome: | 14q21.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20224 |
| Percent of cancer specimens with mutations: | 1.59 |
| Normal role description: | FANCM binds to ssDNA, but not dsDNA. Required for FNACD2 ubiquitination, which is a crucial step in DNA repair. |