Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRIM22 |
| Gene Name: | TRIM22 |
| Protein Full Name: | E3 ubiquitin-protein ligase TRIM22 |
| Alias: | 50 kDa-stimulated trans-acting factor; GPSTAF50; RING finger protein 94; RNF94; STAF50; Staf-50; TRI22; Tripartite motif 22; Tripartite motif-containing 22 |
| Mass (Da): | 56947 |
| Number AA: | 498 |
| UniProt ID: | Q8IYM9 |
| Locus ID: | 1034 |
| COSMIC ID: | TRIM22 |
| Gene location on chromosome: | 11p15 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.51 |
| Commentary on involvement of protein in cancer: | Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. |