Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | XRN1 |
| Gene Name: | XRN1 |
| Protein Full Name: | 5'-3' exoribonuclease 1 |
| Alias: | SEP1; strand-exchange protein 1 |
| Mass (Da): | 194107 |
| Number AA: | 1706 |
| UniProt ID: | Q8IZH2 |
| Locus ID: | 54464 |
| COSMIC ID: | XRN1 |
| Gene location on chromosome: | 3q23 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19627 |
| Percent of cancer specimens with mutations: | 1.3 |
| Normal role description: | 5'-3' exoribonuclease that plays an important role in mRNA decay. Required for processing of the DNA and RNA containing G4 tetraplex. Involved in replication-dependent histone mRNA degradation, meiosis, homologous recombination, telomere maintenance, and microtubule assembly. Suggested to act as tumour suppressor in osteogenic sarcoma. |