Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MIER1 |
| Gene Name: | MIER1 |
| Protein Full Name: | Mesoderm induction early response protein 1 |
| Alias: | HMI-ER1; KIAA1610; Mesoderm induction early response 1; Mesoderm induction early response 1 N1-beta; Mesoderm induction early response 1 N1-beta- ii; Mesoderm induction early response 1 N1-beta-i; MI-ER1; Q9HCG2 |
| Mass (Da): | 60654 |
| Number AA: | 536 |
| UniProt ID: | Q8N108 |
| Locus ID: | 57708 |
| COSMIC ID: | MIER1 |
| Gene location on chromosome: | 1p31.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.37 |
| Normal role description: | Alpha and beta isoform function as transcriptional repressors via recruitment of chromatin remodeling proteins (HDAC1, HDAC2, CBP, G9a) and interaction with transcription factors (Sp1, ER alpha). The alpha isoform inhibits estrogen-stimulated anchorage-independent growth of breast carcinoma cells. |