Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KIAA1967 |
| Gene Name: | KIAA1967 |
| Protein Full Name: | Protein KIAA1967 |
| Alias: | DBC1; DBC-1; Deleted in breast cancer; Deleted in breast cancer gene 1 protein; DKFZp761M0817; K1967; NET35 |
| Mass (Da): | 102902 |
| Number AA: | 923 |
| UniProt ID: | Q8N163 |
| Locus ID: | 57805 |
| COSMIC ID: | KIAA1967 |
| Gene location on chromosome: | 8p21.3; 8p22 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19673 |
| Percent of cancer specimens with mutations: | 0.67 |
| Gene undergoes hypermethylation: | nonsmall cell lung cancer (NSCLC) |
| Normal role description: | KIAA1967 is a nuclear localized protein involved in regulating gene transcription and apoptosis. KIAA1967 regulates transcription through acting as an inhibitor of both SIRT1 deacetylases and SUV39H1 methyltransferases. SIRT1 inhibition increases p53 tumour suppressor protein expression and p53 mediated apoptosis. KIAA1967 can cause apoptosis directly through caspase dependent cleavage leading to release of a C-terminal fragment which can promote apoptosis. KIAA1967's role in cancer development is ambiguous. In some breast and lung cancer cells KIAA1967 was found to be downregulated while in another set of breast cancer samples KIAA1967 mRNA was upregulated. KIAA1967 may act as an oncogene to stabilize and enhance estrogen receptor alpha (ERalpha) which can promote breast and prostate cancer proliferation. In contrast, KIAA1967 may also act as a tumour suppressor protein as decreased expression KIAA1967 either through hypermethylation or deletion was observerd in breast cancer and non-small cell lung cancer. |
| Commentary on involvement of protein in cancer: | Less than 3% mutation in breast. |