Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DOCK4 |
| Gene Name: | DOCK4 |
| Protein Full Name: | Dedicator of cytokinesis protein 4 |
| Alias: | Dedicator of cytokinesis 4; FLJ34238; KIAA0716 |
| Mass (Da): | 225148 |
| Number AA: | 1966 |
| UniProt ID: | Q8N1I0 |
| Locus ID: | 9732 |
| COSMIC ID: | DOCK4 |
| Gene location on chromosome: | 7q31.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19560 |
| Percent of cancer specimens with mutations: | 1.8 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Point mutations are spread out in middle two fifths of the protein with no recorded insertions and deletions. |
| Normal role description: | Activates Rap1. Involved in regulation of adherens junction between cells. Plays a role in cell migration. Injection of wild-type protein suppresses tumour invasion in osteosarcoma mouse cell lines while it is not the case with the Leu-1718 variant. Knockout studies have demonstrated increased propensity for tumour invasion indicating its potential role as a TSP. |