Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PAF1 |
| Gene Name: | PAF1 |
| Protein Full Name: | RNA polymerase II-associated factor 1 homolog |
| Alias: | F23149_1; FLJ11123; Paf1, RNA polymerase II associated factor,; Pancreatic differentiation protein 2; PD2 |
| Mass (Da): | 59976 |
| Number AA: | 531 |
| UniProt ID: | Q8N7H5 |
| Locus ID: | 54623 |
| COSMIC ID: | PAF1 |
| Gene location on chromosome: | 19q13.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19603 |
| Percent of cancer specimens with mutations: | 0.46 |
| Found in amplified chromosomal regions in human cancers: | pancreatic cancer cell line Panc1 |
| Normal role description: | PAF1 is a component of the human PAF complex, which interacts with RNA polymerase II and may be involved in transcription initiation and elongation, histone methylation and monoubiquitination and RNA processing. Overexpression associated with various cancers. Shows oncogenic activity in vivo and in vitro. |