Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SCAI |
| Gene Name: | SCAI |
| Protein Full Name: | Protein SCAI |
| Alias: | C9orf126; CI126; FLJ11758; FLJ36664; MGC120525; MGC120526; MGC120528; NET40; Suppressor of cancer cell invasion; Suppressor of cancer cell invasion protein |
| Mass (Da): | 70381 |
| Number AA: | 606 |
| UniProt ID: | Q8N9R8 |
| Locus ID: | 286205 |
| COSMIC ID: | SCAI |
| Gene location on chromosome: | 9q33.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19670 |
| Percent of cancer specimens with mutations: | 0.58 |
| Commonly recorded point mutations: | Q155H (7) |
| Normal role description: | SCAI is regulator of cell migration and transcription. To faciliate the latter, SCAI inhibits MKL1-induced transcription of the oncoprotein SRF. SCAI also functions through the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway to regulate cell migration. Missense mutations in this gene have been found in breast and ovarian tumors. |