Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STEAP2 |
| Gene Name: | STEAP2 |
| Protein Full Name: | Metalloreductase STEAP2 |
| Alias: | IPCA1; IPCA-1; PCANAP1; Prostate cancer-associated protein 1; Protein upregulated in metastatic prostate cancer; PUMPCn; Six transmembrane epithelial antigen of the prostate 2; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1; STAMP1; STMP |
| Mass (Da): | 55994 |
| Number AA: | 490 |
| UniProt ID: | Q8NFT2 |
| Locus ID: | 261729 |
| COSMIC ID: | STEAP2 |
| Gene location on chromosome: | 7q21.13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.4 |
| Normal role description: | STEAP2 is a membrane bound protein that is involved in iron and copper uptake within cells. It is also a metalloreductase and involved in copper and iron redox reactions. In prostate cancer it is upregulated and promotes cancer progression. |