Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TET1 |
| Gene Name: | TET1 |
| Protein Full Name: | Methylcytosine dioxygenase TET1 |
| Alias: | BA119F7.1; CXXC finger 6; CXXC-type zinc finger protein 6; KIAA1676; LCX; Leukemia-associated protein with a CXXC domain; Ten-eleven translocation 1 gene protein; Ten-eleven translocation-1; Tet oncogene 1; TET1 |
| Mass (Da): | 235290 |
| Number AA: | 2136 |
| UniProt ID: | Q8NFU7 |
| Locus ID: | 80312 |
| COSMIC ID: | TET1 |
| Gene location on chromosome: | 10q21 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.1 |
| Deregulated in translocations: | t(10;11)(q22;q23): MLL-TET1 (in MLL) |
| Normal role description: | Converts 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). May be involved in cytosine demethylation through deamination and gene silencing induced by cytosine methylation. Preferentially binds to CpG islands. |