Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KDM2B |
| Gene Name: | KDM2B |
| Protein Full Name: | Lysine-specific demethylase 2B |
| Alias: | [Histone-H3]-lysine-36 demethylase 1B; CXXC2; FBL10; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; FXLA; JEMMA protein; JHD1B; JHDM1B; Jumonji C domain-containing histone demethylase 1B; Lysine (K)-specific demethylase 2B; PCCX2; Protein containing CXXC domain 2 |
| Mass (Da): | 152615 |
| Number AA: | 1336 |
| UniProt ID: | Q8NHM5 |
| Locus ID: | 84678 |
| COSMIC ID: | KDM2B |
| Gene location on chromosome: | 12q24.31 |
| Number of cancer specimens: | 20858 |
| Percent of cancer specimens with mutations: | 0.71 |
| Commentary on involvement of protein in cancer: | Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. |