Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AKR7L |
| Gene Name: | AKR7L |
| Protein Full Name: | Aflatoxin B1 aldehyde reductase member 4 |
| Alias: | AFAR3; Aflatoxin B1 aldehyde reductase 3; Aflatoxin B1 aldehyde reductase member 3; Aldo-keto reductase family 7-like; ARK74; EC 1.-.-.- |
| Mass (Da): | 36914 |
| Number AA: | 331 |
| UniProt ID: | Q8NHP1 |
| Locus ID: | 246181 |
| COSMIC ID: | AKR7L |
| Gene location on chromosome: | 1p36.13 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.11 |
| Normal role description: | AKR7Lis involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. This activity may allow for AKR7L to protect the liver from toxic and carcinogenic effects of AFB1, thus, given the latter, it may serve as a tumour suppressor gene. |
| Commentary on involvement of protein in cancer: | Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. AKR7L is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a duplicated pseudogene, and it is therefore represented as such in this Gene record. Alternative splicing results in multiple transcript variants. |