Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CTCFL |
| Gene Name: | CTCFL |
| Protein Full Name: | Transcriptional repressor CTCFL |
| Alias: | Brother of the regulator of imprinted sites;CCCTC-binding factor;CTCF paralog;CTCF-like protein;Cancer/testis antigen 27;Zinc finger protein CTCF-T |
| Mass (Da): | 75717 |
| Number AA: | 663 |
| UniProt ID: | Q8NI51 |
| Locus ID: | 140690 |
| COSMIC ID: | CTCFL |
| Gene location on chromosome: | 20q13.31 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19781 |
| Percent of cancer specimens with mutations: | 0.83 |
| Normal role description: | Functions of this DNA binding protein involve transcriptional control, nuclear architecture and insular function in X-chromosome inactivation. Crucial for gene imprinting in male germline. |