Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SLC30A5 |
| Gene Name: | SLC30A5 |
| Protein Full Name: | Zinc transporter 5 |
| Alias: | Zinc transporter 5; Zinc transporter ZTL1; ZNT5; ZnT-5; ZNTL1; ZTL1 |
| Mass (Da): | 84046 |
| Number AA: | 765 |
| UniProt ID: | Q8TAD4 |
| Locus ID: | 64924 |
| COSMIC ID: | SLC30A5 |
| Gene location on chromosome: | 5q12.1 |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.39 |
| Commentary on involvement of protein in cancer: | Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP. |