Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GADD45GIP1 |
| Gene Name: | GADD45GIP1 |
| Protein Full Name: | Growth arrest and DNA damage-inducible proteins-in |
| Alias: | CKBBP2; CKII beta binding protein 2; CR6 interacting factor 1; CRIF1; G45IP; Growth arrest and DNA-damage-inducible proteins-interactin; Growth arrest and DNA-damage-inducible, gamma interacting protein 1; MGC4667; MGC4758; P53-responsive gene 6; Papillomavirus L2 interacting nuclear protein 1; Plinp1; PLINP-1; PRG6 |
| Mass (Da): | 25384 |
| Number AA: | 222 |
| UniProt ID: | Q8TAE8 |
| Locus ID: | 90480 |
| COSMIC ID: | GADD45GIP1 |
| Gene location on chromosome: | 19p13.13 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.11 |
| Normal role description: | GADD45GIP is a negative regulator of cell cycle. It inhibits cdc2-cyclin b1 kinase and histone H1 kinase. It suppreses G1 to S phase cell cycle progression. In cancers, it is found downregulated allowing for uncontrolled progression through cell cycle. |