Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CYP2W1 |
| Gene Name: | CYP2W1 |
| Protein Full Name: | Cytochrome P450 2W1 |
| Alias: | CYPIIW1 |
| Mass (Da): | 53844 |
| Number AA: | 490 |
| UniProt ID: | Q8TAV3 |
| Locus ID: | 54905 |
| COSMIC ID: | CYP2W1 |
| Gene location on chromosome: | 7p22.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19627 |
| Percent of cancer specimens with mutations: | 0.37 |
| Normal role description: | CYP2W1 is a cytochrome p450 monooxidase enzyme. This enzyme is involved in the oxidation and metabolism of drugs and steroids. CYP2W1 has been found to be highly expressed in colon, adrenal gland, lung and gastric cancers. CYP2W1 overexpression has correlated with an overall worse clinical outcome in colon cancer. The exact role CYP2W1 has in cancer progression is still unknown but is thought to play a role in metabolizing chemotherapeutic drugs such as cyclophosphamide and ifosfamide. |