Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GOLGA5 |
| Gene Name: | GOLGA5 |
| Protein Full Name: | Golgin subfamily A member 5 |
| Alias: | Cell proliferation-inducing gene 31 protein;Golgin-84;Protein Ret-II;RET-fused gene 5 protein |
| Mass (Da): | 82990 |
| Number AA: | 731 |
| UniProt ID: | Q8TBA6 |
| Locus ID: | 9950 |
| COSMIC ID: | GOLGA5 |
| Gene location on chromosome: | 14q |
| Number of cancer specimens: | 20108 |
| Percent of cancer specimens with mutations: | 0.04 |
| Commentary on involvement of protein in cancer: | Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. Defects in GOLGA5 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. |