Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KIAA1524 |
| Gene Name: | KIAA1524 |
| Protein Full Name: | Protein CIP2A |
| Alias: | Protein CIP2A |
| Mass (Da): | 102185 |
| Number AA: | 905 |
| UniProt ID: | Q8TCG1 |
| Locus ID: | 57650 |
| COSMIC ID: | KIAA1524 |
| Gene location on chromosome: | 3q13.13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.73 |
| Normal role description: | KIaa1524 is a transmembrane protein that inhibits PP2A (an inhibitor of the oncoprotein, Akt), and stabilizes Myc in human malignacies. It also promotes anchorage-independent cell growth and tumorogenesis. Mutations in this gene have been associated with ovarian tumors. |