Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PREX1 |
| Gene Name: | PREX1 |
| Protein Full Name: | Phosphatidylinositol 3,4,5-trisphosphate-dependent |
| Alias: | P-Rex1 |
| Mass (Da): | 186203 |
| Number AA: | 1659 |
| UniProt ID: | Q8TCU6 |
| Locus ID: | 57580 |
| COSMIC ID: | PREX1 |
| Gene location on chromosome: | 20q13.13 |
| Cancer protein type: | OP (possibly) |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES (possibly) |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 1.81 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PREX1 is a RAC guanine nucleotide exchange factor which can activate Rac proteins by facilitating GTP exchange. Due to its role in the activation of this pathway, PREX1 may promote cell migration and tumour metastasis, but its mechanism of action has not been elucidated. Its activity can be synergistically activated by PIP3 and beta-gamma subunits of heterotrimeric G proteins. |