Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ADAMTS18 |
| Gene Name: | ADAMTS18 |
| Protein Full Name: | A disintegrin and metalloproteinase with thrombosp |
| Mass (Da): | 135167 |
| Number AA: | 1221 |
| UniProt ID: | Q8TE60 |
| Locus ID: | 170692 |
| COSMIC ID: | ADAMTS18 |
| Gene location on chromosome: | 16q23.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20693 |
| Percent of cancer specimens with mutations: | 2.23 |
| Gene undergoes hypermethylation: | shown to be hypermethylated in 49% of colorectal, 39% of pancreatic and 36% of gastric cancers |
| Normal role description: | Found to be downregulated in several cancers and is thought to act as a tumour suppressor. Binding partners of ADAMTS18 have not been identified and therefore its mechanism remains unclear. |