Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FNIP1 |
| Gene Name: | FNIP1 |
| Protein Full Name: | Folliculin-interacting protein 1 |
| Alias: | Folliculin interacting protein 1; KIAA1961 |
| Mass (Da): | 130601 |
| Number AA: | 1166 |
| UniProt ID: | Q8TF40 |
| Locus ID: | 96459 |
| COSMIC ID: | FNIP1 |
| Gene location on chromosome: | 5q23.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.91 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | FNIP1 is a ubiquitously expressed signalling protein that may be involved in energy and/or nutrient sensing via AMP starvation signals and the mTOR signalling pathway. It is known to interact with the putative tumour suppressor protein folliculin, but its function is unknown. It does not have any domains to suggest function. |