Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZNF384 |
| Gene Name: | ZNF384 |
| Protein Full Name: | Zinc finger protein 384 |
| Alias: | CAG repeat protein 1; CAGH1; CAGH1A; CAS-interacting zinc finger protein; CIZ; NMP4; NP; Nuclear matrix protein 4; Nuclear matrix transcription factor 4; TNRC1; Zinc finger protein 384 (CIZ/NMP4); ZN384 |
| Mass (Da): | 63091 |
| Number AA: | 576 |
| UniProt ID: | Q8TF68 |
| Locus ID: | 171017 |
| COSMIC ID: | ZNF384 |
| Gene location on chromosome: | 12p13.31 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.48 |
| Deregulated in translocations: | TAF15; E2A; EWR1 |
| Normal role description: | ZNF384 is a transcriptional regulator of MMP1, MMP3, MMP7 and COL1A1. Translocation events are implicated in development of abnormal protein and oncogenesis. |