Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AEN |
| Gene Name: | AEN |
| Protein Full Name: | Apoptosis-enhancing nuclease |
| Alias: | Interferon-stimulated 20 kDa exonuclease-like 1 |
| Mass (Da): | 36350 |
| Number AA: | 325 |
| UniProt ID: | Q8WTP8 |
| Locus ID: | 64782 |
| COSMIC ID: | AEN |
| Gene location on chromosome: | 15q26.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.23 |
| Normal role description: | AEN is a direct target of p53 and essential for DNA fragmentation in p53-dependent apoptosis. Active against both single- and double-stranded DNA and RNA, AEN amplifies signals leading to apoptosis induction. |
| Commentary on involvement of protein in cancer: | No transforming mutations were identified in the Atlas of Gene Oncology, the Sanger COSMIC database, or Uniprot for this gene. |