Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RNF139 |
| Gene Name: | RNF139 |
| Protein Full Name: | E3 ubiquitin-protein ligase RNF139 |
| Alias: | HRCA1; Multiple membrane spanning receptor TRC8; Patched related protein translocated in renal cancer; RCA1; RN139; Translocation in renal carcinoma on chromosome 8; TRC8 |
| Mass (Da): | 75994 |
| Number AA: | 664 |
| UniProt ID: | Q8WU17 |
| Locus ID: | 11236 |
| COSMIC ID: | RNF139 |
| Gene location on chromosome: | 8q24.31 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.53 |
| Mutations observed as inherited: | hereditary renal cell cancer |
| Deregulated in translocations: | t(3;8)(p14.2;q24.1) causes disruption of the gene in hereditary renal cell cercinoma |
| Normal role description: | Multi membrane spanning protein, located in the ER. Shown to have E3 ubiquitin ligase activity. May interact with tumour suppressor protein VHL and COPS5/JAB1- a protein responsible for the degradation of tumour suppressor CDKN1B/P27KIP. Negatively regulates cell proliferation through a.o. G2/M arrest and cell death. |