Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PPP1R13L |
| Gene Name: | PPP1R13L |
| Protein Full Name: | RelA-associated inhibitor |
| Alias: | IASPP; IASPP gene; NKIP1; RAI; RelA-associated inhibitor: Inhibitor of ASPP protein: PPP1R13B-like protein: NFkB-interacting protein 1: cDNA FLJ26816 fis, clone PRS06437 |
| Mass (Da): | 89091 |
| Number AA: | 828 |
| UniProt ID: | Q8WUF5 |
| Locus ID: | 10848 |
| COSMIC ID: | PPP1R13L |
| Gene location on chromosome: | 19q13.32 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.69 |
| Normal role description: | PPP1R13L is a protein-serine/threonine phosphatase regulatory protein. It plays an integral role in regulation of apoptosis and transcription by interacting with p53/TP53 and NF-kappa-B proteins. Downregulation of PPP1R13L has been shown to induce apoptosis, which is consistent with upregulation of this gene being found in some colon and breast tissues. |
| Commentary on involvement of protein in cancer: | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. |