Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ORAOV1 |
| Gene Name: | ORAOV1 |
| Protein Full Name: | Oral cancer-overexpressed protein 1 |
| Alias: | Tumor-amplified and overexpressed sequence 1 |
| Mass (Da): | 15354 |
| Number AA: | 137 |
| UniProt ID: | Q8WV07 |
| Locus ID: | 220064 |
| COSMIC ID: | ORAOV1 |
| Gene location on chromosome: | 11q13.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19695 |
| Percent of cancer specimens with mutations: | 0.09 |
| Normal role description: | Involved in apoptosis signalling. Overexpressed in oral cancer as the name implies. Gene expression positively correlated with increasing tumour size and angiogenesis. Involved in apoptosis/survival through inhibition of caspase3 pathway and potentially upregulation of cyclin A, cyclin B1, and CDC2. Downregulation leads to cell death and reduced tumour burden. |