Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STAG1 |
| Gene Name: | STAG1 |
| Protein Full Name: | Cohesin subunit SA-1 |
| Alias: | Nuclear protein stromal antigen 1; SA1; SCC3 homologue 1; Stromal antigen 1 |
| Mass (Da): | 144427 |
| Number AA: | 1258 |
| UniProt ID: | Q8WVM7 |
| Locus ID: | 10274 |
| COSMIC ID: | STAG1 |
| Gene location on chromosome: | 3q22.3 |
| Number of cancer specimens: | 19719 |
| Percent of cancer specimens with mutations: | 1.08 |
| Commentary on involvement of protein in cancer: | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |