Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LMO7 |
| Gene Name: | LMO7 |
| Protein Full Name: | LIM domain only protein 7 |
| Alias: | F-box only protein 20; FBX20; FBXO20; KIAA0858; LIM domain 7; LIM domain only 7; LOMP |
| Mass (Da): | 192710 |
| Number AA: | 1683 |
| UniProt ID: | Q8WWI1 |
| Locus ID: | 4008 |
| COSMIC ID: | LMO7 |
| Gene location on chromosome: | 13q22.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20120 |
| Percent of cancer specimens with mutations: | 1 |
| Normal role description: | LMO7 encodes a protein containing a calponin homology (CH) domain; a PDZ domain; and a LIM domain, and it is thought it plays a role in protein-protein interactions. |
| Commentary on involvement of protein in cancer: | Only 1 oral adenocarcinoma & 1 melanoma sample were included in Sanger COSMIC. 1/58 ovarian- & prostate samples were also mutated. |