Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PHIP |
| Gene Name: | PHIP |
| Protein Full Name: | Uncharacterized protein |
| Mass (Da): | 44558 |
| Number AA: | 398 |
| UniProt ID: | Q8WWQ0 |
| Locus ID: | 55023 |
| COSMIC ID: | PHIP |
| Gene location on chromosome: | 6q14 |
| Cancer protein type: | OP? |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19810 |
| Percent of cancer specimens with mutations: | 1.22 |
| Normal role description: | PHIP is an adapter protein specific for the insulin receptor substrate 1 adapter protein (IRS1). PHIP binding was found to inhibit phosphorylation of IRS1 by the insulin receptor and thus PHIP has a role in regulating insulin signalling. Furthermore, PHIP was found to regulate pancreatic beta cell growth and survival through inhibition of pro-apoptotic caspase 3 and 9. PHIP may have anti-apoptotic properties in other cell types and thus may promote survival of cancer cells. Expression of PHIP has been observed in colorectal and epidermoid cancer cell lines but the exact role of PHIP in cancer development has not been well characterized. |
| Commentary on involvement of protein in cancer: | No entry in Atlasgeneticsoncology.org. Less than 3% mutation in CNS. |