Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SYNE2 |
| Gene Name: | SYNE2 |
| Protein Full Name: | Nesprin-2 |
| Alias: | DKFZP434H2235; KIAA1011; Nesprin-2 gamma; NUA; NUANCE; NUANCE protein; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein; Spectrin repeat containing, nuclear envelope 2; Synaptic nuclear envelope protein 2; Syne-2 |
| Mass (Da): | 796442 |
| Number AA: | 6885 |
| UniProt ID: | Q8WXH0 |
| Locus ID: | 23224 |
| COSMIC ID: | SYNE2 |
| Gene location on chromosome: | 14q23.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19900 |
| Percent of cancer specimens with mutations: | 3.79 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with point mutations over protein length, but no insertions or deletions. |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | SYNE2 forms a link between organelles and the actin cytoskeleton to maintain spatial organization within the cell. It is also involved in nuclear organization and structural integrity. SYNE2 is required for centrosome migration to the apex of the cell during ciliogenesis. Its role in cancer is unknown. |