Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PPM1E |
| Gene Name: | PPM1E |
| Protein Full Name: | Protein phosphatase 1E |
| Alias: | Ca(2+)/calmodulin-dependent protein kinase phosphatase N;CaMKP-nucleus;Partner of PIX 1;Partner of PIX-alpha |
| Mass (Da): | 85242 |
| Number AA: | 766 |
| UniProt ID: | Q8WY54 |
| Locus ID: | 22843 |
| COSMIC ID: | PPM1E |
| Gene location on chromosome: | 17q22 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19781 |
| Percent of cancer specimens with mutations: | 0.8 |
| Normal role description: | PPM1E is a protein serine/threonine phosphatase. PPM1E substrates include calmodulin-dependent kinases and Rho GEF whereby PPM1E functions to inhibit their activty. PPM1E may have a role in regulating morphological changes in the cell through inhibition of actin stress fiber breakdown. Mis-sense mutations of PPM1E have been identified in various cancers but their functional effect has not been well characterized. |