Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STARD8 |
| Gene Name: | STARD8 |
| Protein Full Name: | StAR-related lipid transfer protein 8 |
| Alias: | STAR8; START domain-containing protein 8 |
| Mass (Da): | 112601 |
| Number AA: | 1023 |
| UniProt ID: | Q92502 |
| Locus ID: | 9754 |
| COSMIC ID: | STARD8 |
| Gene location on chromosome: | Xq13.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.81 |
| Normal role description: | STARD8 is a GTPase activating protein specific for RhoA and CDC42 monomeric G-proteins. STARD8 activates the GTPase activity of RhoA/Cdc42 to convert it from an activated GTP bound state to an inactive GDP bound state. SRGAP3 may negatively regulate cytoskeletal reorganization and cell division through its interaction with RhoA/Cdc42. Decreased expression of STARD8 has been observed in breast, ovarian, liver and prostate cancer cell lines indicating a tumour suppressor role for STARD8. Expression of STARD8 in these cancer cell lines inhibit cell proliferation and colony formation. STARD8 may inhibit cancer through negative regulation of Rho G-proteins. Mis-sense and silent mutations of STARD8 have been identified but their functional effects are not characterized. |
| Commentary on involvement of protein in cancer: | No entry in Atlasgeneticsoncology.org |