Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NDRG1 |
| Gene Name: | NDRG1 |
| Protein Full Name: | Protein NDRG1 |
| Alias: | CAP43; Differentiation-related gene 1 protein; DRG1; NDR1; Nickel-specific induction protein Cap43; N-myc downstream regulated 1; N-myc downstream regulated gene 1 protein; Reducing agents and tunicamycin-responsive protein; Rit42; RTP; TDD5 |
| Mass (Da): | 42835 |
| Number AA: | 394 |
| UniProt ID: | Q92597 |
| Locus ID: | 10397 |
| COSMIC ID: | NDRG1 |
| Gene location on chromosome: | 8q24.22 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19730 |
| Percent of cancer specimens with mutations: | 0.4 |
| Deregulated in translocations: | NDRG1-ERG |
| Normal role description: | Stress response gene which is upregulated by homocysteine and hypoxia. NDRG1 is a metastasis suppressor gene that is downregulated in prostate, colon and breast cancers, whereas it is upregulated during colon epithelial cell differentiation and in other tumors. Regulated by hormones (androgens and estradiol). It is necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Positively regulated by PTEN. C-myc and N-myc downregulate NDRG1 expression by directly binding to the promotor. Plays a role in cell and lipid trafficking. |