Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HSPH1 |
| Gene Name: | HSPH1 |
| Protein Full Name: | Heat shock protein 105 kDa |
| Alias: | 42 degrees C-HSP; Antigen NY-CO-25; H105; Heat shock 105kDa/110kDa protein 1; Heat shock 110 kDa protein; Heat shock-related 100 kDa protein E7I; Heat-shock protein 105 kDa; HS105; Hsp105 alpha; HSP105A; HSP105B; HSP110; HSP-E7I; KIAA0201; NY-CO-25 |
| Mass (Da): | 96865 |
| Number AA: | 858 |
| UniProt ID: | Q92598 |
| Locus ID: | 10808 |
| COSMIC ID: | HSPH1 |
| Gene location on chromosome: | 13q12.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.63 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | HSPH1 is a heat shock protein that prevents the aggregation of denatured proteins in cells under severe stress. It is overexpressed in cancer cells, but its role is unknown. |