Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LPAR1 |
| Gene Name: | LPAR1 |
| Protein Full Name: | Lysophosphatidic acid receptor 1 |
| Alias: | LPA receptor 1; LPA-1; Lysophosphatidic acid receptor Edg-2 |
| Mass (Da): | 41109 |
| Number AA: | 364 |
| UniProt ID: | Q92633 |
| Locus ID: | 1902 |
| COSMIC ID: | LPAR1 |
| Gene location on chromosome: | 9q31.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19557 |
| Percent of cancer specimens with mutations: | 0.49 |
| General distribution of mutations: | Only 2 sites |
| Normal role description: | LPAR1 is a G-protein coupled receptor for lysophatidic acid, a potent lipid derived mitogen which promotes cell proliferation. LPAR1 will associate with Gi, Gq or G 12/13, G alpha proteins as signal amplifiers. Due to LPAR1 role in activating cell abberant expression of LPAR1 have been implicated in various cancers through unregulated signalling. LPAR1 may also have a role in promoting metastasis of certain cancers. |