Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PRCC |
| Gene Name: | PRCC |
| Protein Full Name: | Proline-rich protein PRCC |
| Alias: | Papillary renal cell carcinoma translocation-associated gene protein |
| Mass (Da): | 52418 |
| Number AA: | 491 |
| UniProt ID: | Q92733 |
| Locus ID: | 5546 |
| COSMIC ID: | PRCC |
| Gene location on chromosome: | 1q21.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20256 |
| Percent of cancer specimens with mutations: | 0.39 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | t(X;1)(p11.2;q21.2) with TFE3 in renal cell carcinoma |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PRCC is a cell cycle protein that regulates cycle progression through interactions with MAD2L2. It may also play a role in pre-mRNA splicing. A t(X;1)(p11.2;q21.2) translocation with TFE3 was found in patients with papillary renal cell carcinoma. However, its mechanism has not been elucidated. |