Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HDAC2 |
| Gene Name: | HDAC2 |
| Protein Full Name: | Histone deacetylase 2 |
| Alias: | HD2; Histone deacetylase 2 variant; RPD3; YAF1; YY1 transcription factor binding protein; YY1BP |
| Mass (Da): | 55364 |
| Number AA: | 488 |
| UniProt ID: | Q92769; Q59GB9 |
| Locus ID: | 3066 |
| COSMIC ID: | HDAC2 |
| Gene location on chromosome: | 6q22.1 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20149 |
| Percent of cancer specimens with mutations: | 0.42 |
| Mutations observed as inherited: | hereditary non-polyposis colorectal carcinoma |
| Normal role description: | Deacetylates lysines on core histones. Acts as a transcriptional repressor through chromatin remodelling. HDAC2 is a key regulator of genes regulating cell cycle, apoptosis, cell adhesion and migration. Also regulates gene expression through the deacetylation of specific transcription factors. |