Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MYST3 |
| Gene Name: | MYST3 |
| Protein Full Name: | Histone acetyltransferase MYST3 |
| Alias: | KAT6A; Monocytic leukemia zinc finger protein; MOZ; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYS3; MYST histone acetyltransferase (monocytic leukemia) 3; MYST histone acetyltransferase 3; Runt-related transcription factor binding protein 2; RUNXBP2; Zinc finger protein 220; ZNF220 |
| Mass (Da): | 225028 |
| Number AA: | 2004 |
| UniProt ID: | Q92794 |
| Locus ID: | 7994 |
| COSMIC ID: | MYST3 |
| Gene location on chromosome: | 8p11 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19831 |
| Percent of cancer specimens with mutations: | 1.51 |
| Deregulated in translocations: | Acute myelomonocytic or monocytic leukaemia, fusion partner NCOA2 (less than 10 cases), CREBBP (<1%), EP300 (Less than 5 cases). Myelodysplastic syndrome, fusion partner is ASXL2. |
| Normal role description: | MYST3 is a histone acetyltransferase that is specific for lysine residues of histone H3 and H4 subunits. MYST3 regulates epigenetic modifications of chromatin to control transcriptional repression or activation. Mutations in MYST3 detected in cancers are not well characterized functionally but may have a role in aberrant MYST3-mediated modifications to oncogenes/tumour suppressor proteins. The MYST3 locus has been found to participate in rare translocation events resulting in fusion proteins which have been implicated in leukemias. These fusion proteins have been found to disrupt normal transcription of genes. |
| Commentary on involvement of protein in cancer: | Less than 3% mutation in CNS. |