Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GGH |
| Gene Name: | GGH |
| Protein Full Name: | Gamma-glutamyl hydrolase |
| Alias: | Conjugase; Conjugase, folylpolygammaglutamyl hydrolase; EC 3.4.19.9; Folylpolygammaglutamyl hydrolase; Gamma-Glu-X carboxypeptidase; GH |
| Mass (Da): | 35964 |
| Number AA: | 318 |
| UniProt ID: | Q92820 |
| Locus ID: | 8836 |
| COSMIC ID: | GGH |
| Gene location on chromosome: | 8q12.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.29 |
| Mutations observed as inherited: | Childhood acute lymphoblastic leukemia |
| Gene undergoes hypermethylation: | Childhood acute lymphoblastic leukemia; Colorectal cancer |
| Normal role description: | Catalyzes the removal of gamma-linked polyglutamates |