Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NRCAM |
| Gene Name: | NRCAM |
| Protein Full Name: | Neuronal cell adhesion molecule |
| Alias: | Bravo; Ng-CAM-related; NgCAM-related cell adhesion molecule; Nr-CAM |
| Mass (Da): | 143890 |
| Number AA: | 1304 |
| UniProt ID: | Q92823 |
| Locus ID: | 4897 |
| COSMIC ID: | NRCAM |
| Gene location on chromosome: | 7q31.1-q31.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 1.1 |
| Normal role description: | NRCAM is a cell adhesion molecule (CAM), which are members of the immunoglobulin superfamily. NRCAM binds ankyrin in neuron-neuron interactions. Mutations leading to upregulation of this gene have been found in brain, colon, skin, pancreatic, and thyroid tumors. Loss of function of this gene could decrease cell adhesion and thus aid in metastisis of neoplastic cells. |