Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CORO2A |
| Gene Name: | CORO2A |
| Protein Full Name: | Coronin-2A |
| Alias: | CLIPINB; coronin, actin binding protein, 2A; IR10; WDR2 |
| Mass (Da): | 59763 |
| Number AA: | 525 |
| UniProt ID: | Q92828 |
| Locus ID: | 7464 |
| COSMIC ID: | CORO2A |
| Gene location on chromosome: | 9q22.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19719 |
| Percent of cancer specimens with mutations: | 0.5 |
| Normal role description: | CORO2A belongs to the WD repeat protein family. It mediates Toll-like receptor-induced NCoR turnover by a mechanism involving interaction with oligomeric nuclear actin, leading to depression of inflammatory response genes; and also regulates cell motility by binding to actin. |