Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CASP10 |
| Gene Name: | CASP10 |
| Protein Full Name: | Caspase-10 |
| Alias: | ALPS2; Apoptotic protease Mch-4; CASP-10; CASPA; EC 3.4.22.-; EC 3.4.22.63; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-convert; ICE-like apoptotic protease 4 |
| Mass (Da): | 58951 |
| Number AA: | 521 |
| UniProt ID: | Q92851 |
| Locus ID: | 843 |
| COSMIC ID: | CASP10 |
| Gene location on chromosome: | 2q33-q34 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.45 |
| Mutations observed as inherited: | LOH associated with familial non-Hodgkin lymphoma |
| Normal role description: | Caspase-10 is a cell death-related protease that promotes apotosis. Defects in Caspase-10 are related to familial non-Hodgkin lymphoma and gastric cancer. |