Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SEMA4D |
| Gene Name: | SEMA4D |
| Protein Full Name: | Semaphorin-4D |
| Alias: | (semaphorin) 4D; C9orf164; CD100; coll-4; FLJ39737; M-sema G; M-sema-G; sema domain, immunoglobulin domain (Ig) transmembrane domain (TM) and short cytoplasmic domain,; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain 4D; SEMAJ |
| Mass (Da): | 96150 |
| Number AA: | 862 |
| UniProt ID: | Q92854 |
| Locus ID: | 10507 |
| COSMIC ID: | SEMA4D |
| Gene location on chromosome: | 9q22.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.73 |
| Normal role description: | Receptor on lymphocytes that binds to plexins (adjacent cell-surface receptor). Coupled to the intracellular G-protein signalling pathway as well as RTK signalling pathways. Overall function promotes angiogenesis, proliferation, and prevents apoptosis. |