Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KLK6 |
| Gene Name: | KLK6 |
| Protein Full Name: | Kallikrein-6 |
| Alias: | Neurosin;Protease M;SP59;Serine protease 18;Serine protease 9;Zyme |
| Mass (Da): | 26856 |
| Number AA: | 244 |
| UniProt ID: | Q92876 |
| Locus ID: | 5653 |
| COSMIC ID: | KLK6 |
| Gene location on chromosome: | 19q13.3 |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.34 |
| Commentary on involvement of protein in cancer: | Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. |