Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GATA6 |
| Gene Name: | GATA6 |
| Protein Full Name: | Transcription factor GATA-6 |
| Alias: | GATA binding factor-6; GATA binding protein 6 |
| Mass (Da): | 60033 |
| Number AA: | 595 |
| UniProt ID: | Q92908 |
| Locus ID: | 2627 |
| COSMIC ID: | GATA6 |
| Gene location on chromosome: | 18q11.1-q11.2 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.4 |
| Normal role description: | GATA6 is a site-specific transcription factor involved in regulating cellular development and terminal differentiation. In mice models GATA6 is required for the development of organs including the lung, heart and pancreas and is required in maintaining this differentiation. GATA6 activity is regulated through interaction with other factors including Friends of GATA (FOG) proteins, GATA4, Tbx5 and Nkx2. GATA6's role in cancer development is dubious and context specific. Overexpression of GATA6 in pancreatic cancer was observed in nearly 50% of tumour samples and stimulated cell growth and proliferation. However, decreased expression of GATA6 and mislocalization to the cytoplasm was observed in ovarian cancers which lead to a dedifferentiation of cells leading to a cancer phenotype. |