Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BAD |
| Gene Name: | BAD |
| Protein Full Name: | Bcl2 antagonist of cell death |
| Alias: | BBC2; BBC6; Bcl- XL/Bcl-2 associated death promoter; Bcl-2 binding component 6; Bcl2-antagonist of cell death; BCL2-associated agonist of cell death; BCL2L8; Bcl-2-like 8 protein; Bcl-xL/Bcl-2 associated death promoter |
| Mass (Da): | 18392 |
| Number AA: | 168 |
| UniProt ID: | Q92934 |
| Locus ID: | 572 |
| COSMIC ID: | BAD |
| Gene location on chromosome: | 11q13.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20338 |
| Percent of cancer specimens with mutations: | 0.09 |
| Normal role description: | Bcl protein - proapoptic. When dephosphorylated and in its active form, Bad primarily binds to Bcl-X, and to a lesser extend to Bcl-2 and Bcl-W, thereby inhibiting their antiapoptotic function. Phosphorylted Bad binds to 14-3-3 proteins and is inactivated. Proteins that phosphorylate Bad involve PKA, AKT/PKB and RAF1. |