Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: ARHGEF2
Gene Name: ARHGEF2
Protein Full Name: Rho guanine nucleotide exchange factor 2
Alias: GEFH1; GEF-H1; Guanine nucleotide exchange factor GEF-H1; Proliferating cell nucleolar antigen p40; Rho/rac guanine nucleotide exchange factor 2
Mass (Da): 111543
Number AA: 986
UniProt ID: Q92974
Locus ID: 9181
COSMIC ID: ARHGEF2
Gene location on chromosome: 1q22
Cancer protein type: OP
Effect of cancer mutation on protein: GAIN
Effect of active protein on cancer: PROMOTES
Number of cancer specimens: 19718
Percent of cancer specimens with mutations: 0.82
Normal role description: Acts as a guanine nucleotide exchange factor for Rho-GTPase. Exchange GDP to GTP and activates Rho-GTPases. May involved in epithelial barrier permeability, cell motility and polarization, antigen presentation, cell cycle regulation and cancer.


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