Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DLX4 |
| Gene Name: | DLX4 |
| Protein Full Name: | Homeobox protein DLX-4 |
| Alias: | Beta protein 1;Homeobox protein DLX-7;Homeobox protein DLX-8 |
| Mass (Da): | 26263 |
| Number AA: | 240 |
| UniProt ID: | Q92988 |
| Locus ID: | 1748 |
| COSMIC ID: | DLX4 |
| Gene location on chromosome: | 17q21.33 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.25 |
| Normal role description: | DLX4 plays a role in forebrain and cranicofacial development, cell survival and proliferation and reduced apoptosis. It has been found to positively regulate Bcl-2 expression, decrease caspase 7, 8 and 9 cleavage to develop resistance to apoptosis. It has also been found to increase expression of PARP and decrease expression of BRCA1. Dysregulation can lead to increased cell proliferation in cancers. |