Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LPP |
| Protein Full Name: | 5 kDa protein |
| Mass (Da): | 4925 |
| UniProt ID: | Q93052 |
| Locus ID: | 4026 |
| Gene location on chromosome: | 3q27-q28 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20357 |
| Percent of cancer specimens with mutations: | 0.54 |
| Deregulated in translocations: | t(3;12)(q27;q15): HMGA2-LPP; t(3;12)(q27q15):C12ORF9-LPP; t(3;11)(q27;q23): MLL-LPP; t(3;3)(q27;q27): BCL6-LPP; t(3;6)(q27;p21): HMGA1-LPP |
| Normal role description: | Suggested to be involved in cell adhesion, signalling events and direct activation of gene transcription. Precise function not fully understood. Fusion protein HMGA2/LPP due to translocations is involved in benign tumors of lung, adipose tissue and cartilage. MLL/LPP fusion protein in AML. |